Newly isolated sporopollenin microcages from Cedrus libani and Pinus nigra as carrier for Oxaliplatin; xCELLigence RTCA-based release assay

Sporopollenin-mediated control drug delivery has been studied extensively owing to its desirable physicochemical and biological properties. Herein, sporopollenin was successfully extracted from C. libani P. nigra pollens followed by loading of a commonly known anticancer Oxaliplatin. Drug features were confirmed using light microscopy, FT-IR, SEM TGA. For the first-time, real-time cell analyzer system xCELLigence employed record Oxaliplatin loaded sporopollenin-mediated death (CaCo-2 Vero cells) in real time. Both release assays slow oxaliplatin for around 40–45 h. The expression MYC FOXO-3 genes significantly increased CaCo2 decreased non-cancerous confirming fact that is promoting apoptosis preventing spread negative effects on nearby healthy cells. All results suggested can be suitable candidates drugs.